Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods
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چکیده
منابع مشابه
Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods
BACKGROUND Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (IV). These three methods define participant compliance dichotomously, but part...
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ژورنال
عنوان ژورنال: Trials
سال: 2015
ISSN: 1745-6215
DOI: 10.1186/s13063-015-1044-z